I had to chime in here because my H (in a similar work situation as yourself and Matilda's H) said pretty much the same thing to me saturday. It's very hard to watch our S go through tough work stuff - it seems a little like depression. And WHAT's in the water anyway..so many people dealing with this stuff right now..
I know full well that I should just listen and say what your wife said to you or "It sounds like that is really tough for you, I'm sorry". I do that, and usually some kind of advice creeps in there too. Tryong to quit that.
I was also wondering today if there are other ways to help subtly... Boost our S's confidence or esteem in other ways without them noticing. I don't know... Plan stuff they can look forward to? Help alleviate other areas of worry? It's a hard balance to not get overly involved in their "stuff".