Its strange TMU, I've heard similar things from my W during this thing. Typically, she questions whether she was ever happy during her life and how she just wants to "go" (I would embellish here, but this is about your sitch, not mine).
I guess I attribute a lot of this to the whole situation in front of them. They are depressed because, on one hand they see a "life" that seems to promise more, but on the other hand, they don't want to lose the life they've built. Its very hard for them as well. I can see that in my W because she's very torn at times.

That being said, what to do in your situation. You may want to touch upon it with her, just to let her know that some of the things she said concerned you deeply. You're right, she will likely downplay them as drunk psycho-babble, and to some degree, it probably was. But in any event, let her know that you understand what pain this is causing her and also reassure her that you want whats best for her. I wouldn't flat out encourage her to be with OM, becuase quite truthfully, but encourage her to do what will make her happy. Its hard to understand, but its not so much which to choose which makes her unhappy, its the fact that she has to choose that is (if that makes any sense).

Good luck TMU and keep us posted.

"Achieve success, but without vanity; Achieve success, but without aggression; Achieve success, but without gain; Achieve success, but without force." Lao Tzu