This to me is bizarre as for the last 11 years we had a strong marriage, a very nice house, good careers, and most importantly, two beautiful and smart children. Going nowhere?

Some people develop a problem with stability. They want something exciting, thrilling, they see stability as boring. They see sameness everyday and project it out to the future. Could be she thinks of her friends or mom or someone who was in a "normal" family thing but had regrets about life and is scared about ending up that way. It's not aliens, its the human condition. You're talking details, she's talking feelings.