Indifference usually begins about 18-24 months prior to the bomb drop. When a person is depressed, they have no desire to be happy about anything. It's a struggle to get through the day for some. Take some time and read up on depression. If you check out the resources thread that smurf created many years ago, which is one of the threads above and is one of the stickies, it may provide you with a lot of sage advice.
When does indifference start to fade? When the person who is suffering starts to wake up and begin to look around and become curious about life, i.e., children, spouse, parents, pets, friends, co-workers, etc. This generally does not begin until closer to the end of the crisis.
If you don't already know this...depression is the main ingredient of MLC. Depression comes in all shapes and sizes and how it is not a "one size fits all" when it comes to the symptoms.
Sit quietly, the answers will reveal themselves when you least expect them to. The past is gone, the present is a gift and you need to focus on today, allow the future to reveal itself when it is ready.