Please think back to 18-24 months....did something happen? Death of family member/close friend, new job, lost a job, became an empty nester, health issues? Something triggered her unhappiness and she's trying to figure out what is wrong w/her and why she feels the way that she does.
For now, I would listen and validate her thoughts/feelings. I would not give advice unless she asks for it. Be a friend who listens. Don't push or put pressure on her to come back into the marriage. The comments that she has made are typical MLC jargon.
Continue working on you, make the changes for you and if you are happy w/them, then make them a permanent part of your life. Focus on your family and give her all of the time and space she needs.
Sit quietly, the answers will reveal themselves when you least expect them to. The past is gone, the present is a gift and you need to focus on today, allow the future to reveal itself when it is ready.