Wow Ste7e, I am also in education! I'm still in it, but I know the burnout oh too well.
The lack of empathy from your wife during the tough time you endured with the passing of so many people close to you is striking. Was she always like that or do you think she had already begun to close off and detach from you? If that is her general personality I would think long and hard about whether that is the type of person you want to be in a long term R with.
I also got the "I wish I had never married" I think that is part of the script.
I don't think you can focus on turning the R around right now. Focus on turning yourself around. Work on the job front - I have to imagine that would help your self-esteem and GAL efforts a ton. If you get yourself in a good place you will be ready for a healthier relationship, with the W or with anyone else.
W 34 Me 42 Married 7 years together 8 0 kids 1 beloved dog BD 4/6/2018 I moved out 4/7/2018 I moved back in alone 8/05/2018 I file 3/06/2019 D official 5/7/2019