Yes, it's the domino effect. feeling of drifting apart, the loss of connection, then the actual drifting apart, then once things are bad, you've probably heard people talk about "we only see our past through the lenses of today" (or something like that...)
Basically if things are bad, we remember all the bad things and none of the good stuff. and vice versa. When your mind is consumed with nothing but all these negative memories, feelings, emotions, fears, etc... it leads to any sorts of things, but almost always something negative.
Resentment/Contempt/Worry/Anger... these are all just forms of fear and/or hurt, usually some form of the two mixed together. In my W's case... she "tried for so long" (albeit, with improper methods, and my neglect), and eventually, she just ran out of gas... once that happened all her attempts at reaching out to me (cries for help, if you will), stopped, and her own hurt transformed into hatred and contempt for me and "what I had done to us".