EMMess, man sorry you are going through such a painful situation with your W, she really has no regard for you or the kids, make sure you document all of that with pictures, texts, notes.
Medication will help but ur W will still be stepping all over you, I would ask her to leave, google Fathers right and get a feee lawyer and get custody of the kids ASAP.
She will not change because she doesn't have to, she gets to come home whenever to her family when she decides.