1) how sure are you of this affair? 50%? 90%? 99%? Are you prepared to be the cause of ruining their marriage if the 1/10/50% case is the truth?
2) as Starsky said, are you strong enough to do with the blowback from this? If you do expose this, things will get a LOT worse. I'm sure there are multiple threads out there with some examples. Mahone flushing a junkie's stash down the toilet. YOU are now solely responsible for crushing this and you will be blamed. Are you strong enough to deal with it now?
3) what do you hope to gain from this? How does this help you reach your goals.
Not saying you should or shouldn't take this step. But it's a HUGE step and there's no going back once you open that door.