I say go for it. This is a great opportunity for you and you have been considering a change for quite some time. As for your peeps, I would consider hiring someone on the days that you would travel and your x-inlaws can help out some too. Your peeps aren't little babies that require someone overseeing them every minute of the day. There are people out there that would love to have the opportunity to be there to get them off to school, etc., i.e.

There is no guarantee that you will be traveling 5 days per month. Some months you may not travel at all. They have to advise you of this so that you aren't caught unawares when travel may be necessary.

I definitely would think on this one and the positives sound like they outweigh the negatives for you. If you are concerned about the children, talk to them about it and see what they think. They may think of it as an adventure if mom is gone a couple nights a month or they may say that they don't like the idea of having someone else taking care of them.

I'm sure that you will make the right decision not only for you, but for your children as well.

Sit quietly, the answers will reveal themselves when you least expect them to.
The past is gone, the present is a gift and you need to focus on today, allow the future to reveal itself when it is ready.