There is definitely a difference between "letting go" and "giving up," Rys. It took me awhile to finally get that, and to accept it. For me, it made it easier to give her to GOD, but regardless, you have to come to the full-on realization that YOU CANNOT CONTROL HER, AND YOU SHOULDN'T WANT TO.
That's not easy for us guys, who are by nature fixers/problem-solvers.