I just thought I'd jump in here and say that I think 200 years ago, there was no one talking about happiness and "are you really happy?" It was simply about getting through the day and surviving. Your day/life was about work and making ends meet. Now we put so much value in "are we happy" and I think that is what sends people off the deep end. Just looking around on the internet and you see taglines like "having it all" and "being happy" and it's no wonder that people wonder what they're missing out on.. there is always something better.
I may not be articulating myself the best (had a long family lunch w/- alcohol) but that's my 0.2 cents!