There are a few things you might do to get rid of that "empty house" feeling.
Ultimately, you may want to create your "bat cave" in a room. A place that is comfortable and has all you ever want to keep you entertained and engaged.
You need to feel comfortable in your home, even if you are alone. That might help.
Also, get out. If you are feeling lonely, go do something with friends if possible, or at least go somewhere that there are people. Even if it is taking a book with you and sitting at a local coffee shop for an hour, reading.