My W is on Zoloft, I think 100 mg. A while back (after BD of course) I started looking into this and there seems to be quite a bit of data suggesting that some of these A/D's can not only cause people to fall out of love with their spouse, but just lose the ability to be "in love" completely. My W started on it about 10 years ago (to address deep post-partum depression) and her personality changed significantly after she started it. Before that we would have intense arguments and crazy monkey-love make-up sessions afterwards. Afterwards she just never, ever argued about anything. If an argument would escalate, she would shut down. I talked to her a few times over the years about going off Zoloft, but she wasn't willing. She just remembers that black hole she was in when she went on it and she's scared of going back to that again.
There seems to be some mystery regarding SSRI's- about how exactly they work and what the long term effects may be. I think in general doctors realize there are negative long-term impacts, but it's a case of the lesser of two evils- deep depression with possible suicidal tendencies or little/ no depression with possible long-term relationship damage.
