The other scenerio is that she has entered into a mid-life crises, like my wife has. "I want to be independent and find out who I am" was something I heard that sounds similar to what your W told you.
No other man in my wife's life, (yet) but she's convinced she doesn't want me. She's moved out of our bed, and yes, makes sure I no longer even see her change. Oh, started doing plenty of exercise too. Lost 20 pounds in 3 months. Looks hot, but not for me.