This is a shot in the dark, but I wanted to add my 2c.
I've exhibited many of the symptoms like your wife but to a more mild degree. About 10 years ago, we tried to adopt a more healthy diet. In doing so, we added more whole grains (mainly whole wheat). Apparently, I developed an allergy to it and went downhill mentally and physically.
It was baffling because the rest of my family was thriving. At one point, my H said he would pay $10K to find out what was wrong with me.
About three years ago I removed all nightshades and gluten from my diet. After about a year of detox, I now live peacefully and my health has never been better.
Of course, it's a huge sacrifice to eat this way, but what price for mental and physical health?
I couldn't help but want to share this when I read the list of your wife's symptoms.
Like I said....a shot in the dark....but just wanted you to know this possibility.
Me54/H47 '08 H is "done" March '12 H moved out Brink of D, December '12 2014 totally reconciled! ...... "I firmly believe in the...absolute possibility of marriage renewal." Jim Conway