Quote: She was telling her that while she was off the meds she was severly depressed. I don't know if this is one of the symptoms of inactive thyroid but I think it is more of what is really going on with her
Hypothyroidism can DEFINITELY cause symptoms of depression, so you really won't know if there is an underlying depression until her thyroid is fully treated. 50 mcg is a fairly small "beginner" dose - most people require more to be "right" = at least 75, sometimes up to 150. She should definitely get a blood test after 6 weeks on this dose and get her dosage adjusted up if needed. Remember what I told you about the TSH - although the "normal" lab range in the past has been 0.5 to 5.0, current thinking by endocrinologists is that you should shoot to get it between 1 and 2, and this is what infertility docs have found is the optimum for fertility, so make sure your W pushes her doc to get her up into that range (remember TSH goes down as thyroid hormone levels go up).