Not specifically... the problem is that there isn't good knowledge on the actual biochemical mechanisms that make Wellbutrin work, therefore it's hard to determine why it does what it does.

My W was prescribed it in order to stop smoking. Though, that was a cover on her part to a degree since she was incredibly depressed and needed something. Since it was for smoking cessation her general practitioner could prescribe it. Last night she revealed to me that while we were on vacation in August (where she was incredibly distant and disengaged... I felt like I was alone on vacation) she was having constant suicidal ideations and thoughts. Most likely this was related to the start of the Wellbutrin regimen as it's a known side effect of starting it.

As far as its effect on Rs, both my C said that studies have shown Wellbutrin is terrible for helping people with depression and in marriages. For whatever reason is effects the brain chemistry surrounding making bonds. Combine my W's alcohol use with this and it's just an extra bigger mountain to overcome.

I simply tossed out last night during our talk that maybe once she is in IC she should discuss her regimen. No pressure, no direction just concern for her. I suspect her IC will see that and possibly consult with a psychiatrist to see if the med selection is the best option.

Here's an article that gets a little more into it, particularly related to the dopamine formation and uptake issues surrounding SSRIs:
Article on SSRIs and relationships

The article focuses a little more heavily on sex than just Rs, but I can see a lot of it in my W. Particularly the difficult getting to O... she still can but it takes much more than it ever did before. Whether that's our R or the meds or both... that's the maddening part.


Married 6 together 8
Me:38 W:31 second marriage for both
SS12, SD10, S6
Bomb: 9/8/11 (day before our 5 yr ann)
W moved out: 2/18/12
D final: 11/12/12
Share S 50/50. Spend as much time as I can with SS & SD