AC, yep, I've felt like a reject, too, so I know where you're coming from. Your W is in this emotional pit, and you have been more than willing to hold your hand out to help her get out of it. She has chosen a solution to her woes that IMO is not a good one.
Now is the opportunity to find YOU, to work on yourself, and ultimately become your best self.
I am glad your knee is feeling better and you're getting back to the gym. I know that's has to help.
Is there anything you can do to be around other people? I think that may help, too.