What makes you think you can control whether you get divorced or not?
Is your wife on bipolar meds? Abilify, lithium, tegretol? If she is not on any of these, then say your prayers.
My daughter and mother are both bipolar, my wife is MLC. One of the things I have learned is that you can not control mental illness.
So to answer your question, no you do not confront your wife. Let her go and detach from her. It is like squeezing a bar of soap. If you hold on too tight it slips away.