I just read this caption from the alcoholics anonymous "big book" last night. It describes ones Rock Bottom:

"One definition of a bottom is the point when the last thing you lost or the next thing you are about to lose is more important to you than the booze" (Alcoholics Anonymous World Services, Inc., 2001)

In case of midlife crisis, I am sure you could substitute the word "booze" for anything they are seeking: pleasure, youth, OW, money, prestige,bars/clubs, attention.....etc...

This is exactely the point my brother got to when he hit his. He desired his own life over booze, and got sober and I am so proud of him - he is a rock. I went to an A.A. meeting with him for my first time today and an alanon by myself. The a.a. meeting was eye opening for me. They really cant control the power of alcohol with out a higher power, thank God some of them have found that higher power.
TIPPER