Sinclair.
I know you know this but your wife really, really needs to consistent with her medication for depression for it to be effective at all. Is there any way to broach this with her or her doc? is she getting the meds from her family doctor or psychiatrist. Many family docs just write scripts without really looking into the issue. A psych doc would be able to find the right med that would work for her.

This is a sticky issue because depression can cause a host of issues an gives a person fuzzy thinking. I wouldn't trust any decision she made based on the fact that her meds are all over the place. Maybe should could try something else, if she had issue with Prozac.

Many docs will give patients something for anxiety. The old-school docs call them tranquilzers.