Hmmmmm....both are definite possibilities, Barb. Generics sometimes aren't absorbed as well (differences in fillers and the like) so you might end up with a lower level of the meds in the blood (plus counterfeit drugs are a problem occasionally). Were they able to measure his blood levels of his meds when he came in? Were they low?

Flu shot is another possibility - while adverse effects are rare, any vaccine can have a low rate of reaction - usually accompanied by fever. If he didn't have any fever, it's also possible for the flu shot to ramp up immunity in general - including any autoimmune antibodies? Have they ever thought that autoimmunity could be an issue?

(Also - FWIW for others out there - people with celiac disease who are sensitive to gluten, may have problems when switched to a drug that contains gluten in the filler).