You need substantial evidence and there are people better suited to discuss how and if you even have enough to confront. Just by asking that question you are not in a position to handle any response or reaction he would give.
I've just skimmed through your posts and see that you "think" he might be depressed? Is this still the case?
What have you been doing in regards to handling the R with him? Are you discussing the M at all? Are you pursuing or are you just keeping your distance?