Is her chronic fatigue autoimmune in nature? I ask because I have an autoimmune disease and they can be VERY hard to diagnose.

Just a suggestion but if your W does get yearly blood work she might see about getting an ANA test along with the regular CBC panel.

Without a diagnosis one can't know how to remedy the situation and it doesn't sound like she has a firm diagnosis. The problem with chronic fatigue and other autoimmune disorders is most family dr's are not equipped to deal with it. But without a proper diagnosis a specialist won't see you. I dealt with that for years. Nine years to be exact.

What are the factors that contribute to your W's chronic fatigue?