She will probably always say there's nothing wrong. Typical female answer. You might tell her you noticed that she seemed a bit down and ask her what you can do to help her feel better. All you can do is open the door and if she won't accept the invitation, then don't try to get her to talk. You may have to kid around, tease, etc. to get her out of the mood if she won't talk.
It is not about what you feel should work in your M. It is about doing the work that gets the right results. Do what works!