When do I know when to give up the fight to get him back?
Only you can decide this, however if he had cancer would your thought process change? He has depression. He is trying to find a way to fix his depression. His solution is to get rid of you. I didn't say any of these things make any sense, but that is what is happening.
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Has he really moved on?
He would like to believe that, until he finds out that the quick fix that he has been trying to get didn't work. Then he will move on to someone else or back to you.