As for your friend. He/she pollyanna. Could your wife come out of this? ...yes...if she was struck with amnesia and you got to rebuild her mentally.
I think 'pollyanna' is too nice. These people are unintentionally destructive because they cannot face the fact that there are others in this world who are mentally Ill. Period.
I wish these 'standers' would stop saying things like this to Frank because they are making him DOUBT his own reality. If THEY had any consideration they would shut up and listen.
Here's some news from where I live. Hey 'pollyanna', do you think THIS MARRIAGE could have been saved? According to the article they tried to. But don't ya think that the husband MIGHT have been F'cked up for REAL?