I talked/cried to my brother shortly after ex said he was miserable and wanted to live the life he always wanted. My brother very matter of factly told me that there was another woman, and (..I quote,) "P^ssy is very expensive." I was shocked at the wording but over time understood the meaning.
I was one of those who never wanted to believe a spouse would stray, bolt and end everything. However it was great that I had very supportive and realistic friends and family to help me through it.
It's great that you both can be there in a positive way to someone so close.