I have the same issue that all my friends are mutial with S and not really friends with work people. I have reconneced with a few older friends but none live very close.
You mentioned Meetup and I just used that to meet some new people. Went to a play last weekend and out to sushi and had a great time. It was very hard to go alone to meet new people but I told myself that the first few times would be ackward but I would get to know them and vice-versa and it would be fun. It did make me feel better to get out and meet new people.
I have also gone to a few movies alone. I love movies and didn't feel wierd going alone.
Me-38 W-44 D8 & D6 together '95, Wed '97, Bomb 11/18/08 Still in same house
