Just a quick note as I have to run. I am, by no means, a expert on co-dependence, but having concern for your wife if she is damaging her health and asking if she needs help would not be co-dependent as far as I'm concerned. If her problem started to concern and engulf you more than her, then maybe.
It's a delicate walk, but if there's a real health concern here, just like any other addiction, throw out the DB playbook and help as a H or as a friend.