If it feels right, then it is what you should do. I think we always know in our gut what is right for us. If pursuing this career is what will help keep you moving forward then do it. I agree that we have to look at economic indicators, but ultimately, we need to do what is right for us.
I think the pit in the chest that we feel is also of two sources and I think we mix those up too, or at least I do. I highly recommend tracing the source of any given feeling that is troubling, or good for that matter, because knowing the source tells us how to deal with the feeling.
That said, as you know, I get that empty pain in my chest, too. I have never experienced anything like it before all of this. The human body is a wonder.
As for your wife not communictaing with you, that is today. Tomorrow will bring what it brings but for now, you just keep working with what you have today. I know, follow my own advice, right?