SDF = Louisville LOU = Bowman Field (small general aviation airport on east side of town.
MCI = Mid-Continental International Airport-- the name of Kansas City Int'l previously.
Originally Posted By: Airport Codes: The ABC's
Kansas City, Missouri became MKC and more recently the 'new' Kansas City airport chose MCI. (The code for Kansas City International Airport, MCI, was assigned during the early design phase of the airport when the name was going to be Mid-Continent International. Shortly before it opened, Kansas City officials decided to change the name so people would know what city it was in. It was too late to change the code.)
SDF = Standiford Field -- like many airports, it's genesis was born as a Army Airfield before the World Wars. Standiford was the name of the land owner that sold the property to the gov't.