ODGA -
some people can do fine on a smaller dose (my H, for instance, only takes 10 mg. of prozac - half the usual starting dose - and does well with it). The question of course is: does she feel apathetic because of the meds or because of the depression?

Also - has she shown any signs of bipolar disorder (manic depression) in the past? People with bipolar disorder usually like the feeling of being a little manic and dislike drugs that control that (although that is usually more an issue with lithium than with ADs.)

If she does try cutting down her AD dose, can you get her to take fish oil capsules and exercise regularly? These may help with the depression and offset the decreased dosage.

Ellie