Sorry... I don't agree with the house on the market, moving thing 'cuz where you live isn't the problem. I think the problem will "follow" you. Yes, it will resolve the logistics of things but it won't resolve her craving to have these people in her life. Let's say you do move and then your new neighbors are so wonderful and you're right back where you started or the present neighbors and/or your wife starting spending more time together because of the move and their addiction to each other?
I think your best plan is to try and compromise with her on time spent with them and if that doesn't work, take a harder stance. You are worried about losing her but it sounds like she's moving along that track herself by her not being "in the game" in your marriage.
I also think the "neighbors" aren't your primary problem. I think it is a side effect of your real problem and to me, that is the state of your marriage. I think it's more important to try and see if she'll work on the marriage more than she is and honestly, the other problems like the neighbors will resolve itself if she's willing to do the work. If she doesn't want to work on the marriage like a trooper, then I think you need to make some choices like a separation to show her that you're serious about this and if she doesn't want to work on it, then you don't really need her as a roommate. I'd like to ask her if she's your wife or your roommate and her answer would tell me a lot. If she's your wife, then she needs to work on things more and pull her part. If she's your roommate, then if I were you, as difficult as it is, I would ask her to leave... one option is to then put the house up for sale so that you both leave but seprately. Right now, she's calling the shots based on what I've read and you're kind of letting her but complaining about it. You have every right to stand up for yourself and what you want. Maybe she would have some newly-found respect for you given that.