There are definitely multiple issues here, mostly entertwined. The whole obsession with youth/beauty/ and need for validation, for example. If it was not this guy, it would have been another guy, and I know she had her eye on one before this guy.
As I've stated before, she needs to find where she can live, and enjoy her newfound career and independence and just plain being _____ (her first name), and not just "Mrs. Chocolateeyes" and "Mother of Chocolateeyes' Kids," and she needs to find out if she can find that within our marriage, instead of looking inappropriately for it OUTSIDE of our marriage.
And then there are all of our marital issues, which is really mostly just ONE issue that we've never been able to get past: how to be intimate with each other, and to handle it as an Issue when it rears its head and makes one or both of us unhappy.
But first we have to stop the ooey-gooey chemicals from rushing around her head, because they are making her compound the problem with more bad choices on her part. As Nick Nolte said in North Dallas Forty , "It's time to put away childish things," and to begin working at the marriage and the underlying issues.