I wanted to suggest something that has helped me, and perhaps might help your wife.
I have become a member of www.flylady.net who helps people break down house cleaning into baby steps. This helps my depression because if I keep up with whatever goals I've set for myself, with Fly Lady's help, I feel better a lot of the time. Between Fly Lady and Michele, my life is changing for the better!
Also, I find that taking my Omega 3, 6, and 9 really helps my moods.
Also, for me, fearing that those I love would leave me because of my depression, was something I had to deal with, and still struggle with. I suspect it's a common symptom of depression.
