How do you see issues 5 & 6 as not existing before she became LD? Those are FOO issues that pre-exist you. As GEL says, 2, 3 & 7 are medical issues. Have you discussed them with her? Has she seen a doctor and if so, what was the result? Did she actually get her thyroid tested, as well as her hormone levels? How much overweight is she? What is your physical condition?
I don’t know much about your history (well, you haven’t been too revealing), so can you tell me if you two have ever been to counseling? What came of it, what were the major issues, did any change come about?
Regarding her FOO, why do you say she was “possibly” abused? Did she tell you of this or is it just your suspicion? What type of neglect did she suffer as a child?
How do you feel about her abuse and neglect? Have you ever spoken about this? Have you been empathic about these matters or is it something the two of you do not discuss?
When you mention relationship issues, I know the relationship between you and her is not what you want. Is that the relationship issue you have in mind or are there other issues with other people? If so, who and what are the issues?
Why do you think her drive dropped off 3-4 years ago? What happened at that time that might account for some of the change? Haven’t you been on this board about the same amount of time?