IMS basically sounds like the result of a SSM. I don't see it as a cange in chemicals, it is a change in his marriage that causes it.
Something interesting I have found out about testosterone, the one sure way to reduce testosterone in men is to have them marry. They have found that after men marry, their teststoerone level drops. However, if they become single again, even years later, their testosterone will jump right back to the level they had as singles. So just the presence of the wife will reduce a mans testsoterone.